2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130569S2
    7-Hydroxymethotrexate-d3 ammonium 98%
    7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxymethotrexate-d3 ammonium
  • HY-133851S1
    10-PAHSA-13C4 2705244-93-3 98%
    10-PAHSA-13C4 is the 13C-labeled 10-PAHSA. 10-PAHSA is an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
    10-PAHSA-13C4
  • HY-133970S1
    5α-Cholestane-d2 122241-86-5 98%
    5α-Cholestane-d2 is the deuterium labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research.
    5α-Cholestane-d2
  • HY-135335S1
    3'-Hydroxy Repaglinide-d7
    3'-Hydroxy Repaglinide-d7 is the deuterium labeled 3'-Hydroxy Repaglinide (HY-135335). 3'-Hydroxy Repaglinide is the major CYP2C8 metabolite of Repaglinide (HY-15209). Repaglinide is a carbamoylmethylbenzoic acid (CMBA) derivative that acts on type 2 diabetes.
    3'-Hydroxy Repaglinide-d7
  • HY-135615AR
    Desmethyl Sibutramine hydrochloride (Standard) 84467-94-7 98%
    Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant.
    Desmethyl Sibutramine hydrochloride (Standard)
  • HY-141617S1
    1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d31 98%
    1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d31 is the deuterium labeled 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE (HY-141617). 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring choline phospholipid that can be synthesized from phosphatidylcholine and fatty acids. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is used as a structure-related lipid control.
    1-Palmitoyl-2-hydroxy-sn-glycero-3-PE-d31
  • HY-143712S1
    Allolithocholic Acid-d4 98%
    Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
    Allolithocholic Acid-d4
  • HY-146836S2
    (Rac)-16:0 PI(5)P-d5 diammonium 99.0%
    (Rac)-16:0 PI(5)P-d5 diammonium is deuterium labeled (Rac)-16:0 PI(5)P diammonium.
    (Rac)-16:0 PI(5)P-d5 diammonium
  • HY-16168AS1
    Degarelix-d7 TFA
    Degarelix-d7 TFA (FE 200486-d7 TFA) is the deuterium labeled Degarelix TFA. Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer.
    Degarelix-d7 TFA
  • HY-16168AS2
    Degarelix-d7 TFA-1
    Degarelix-d7 TFA-1 (FE 200486-d7 TFA-1) is the deuterium labeled Degarelix TFA. Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer.
    Degarelix-d7 TFA-1
  • HY-163263S1
    HSD17B13-IN-80-d2 2770247-90-8 98%
    HSD17B13-IN-80-d2 (Compound 200) is the the deuterium labeled HSD17B13-IN-80 (HY-163263). HSD17B13-IN-80 is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI).
    HSD17B13-IN-80-d2
  • HY-17503BS1
    Metoprolol-d6-1 tartrate
    Metoprolol-d6-1 tartrate is the deuterium labeled Metoprolol tartrate (HY-17503B). Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol-d6-1 tartrate
  • HY-32351AS1
    Calcifediol-13C5 monohydrate 98%
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-13C5 monohydrate
  • HY-A0132S11
    N-Acetyl-D-glucosamine-13C,15N-1 98%
    N-Acetyl-D-glucosamine-13C,15N-1 is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-13C,15N-1
  • HY-A0132S12
    N-Acetyl-D-glucosamine-13C6 1194446-34-8 98%
    N-Acetyl-D-glucosamine-13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose-13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132). N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
    N-Acetyl-D-glucosamine-13C6
  • HY-B0144AS3
    Pitavastatin-d4-1 sodium 99.22%
    Pitavastatin-d4-1 (NK-104-d4-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
    Pitavastatin-d4-1 sodium
  • HY-B0162AS1
    Ivabradine-d3 hydrochloride 1217809-61-4 98%
    Ivabradine-d3 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
    Ivabradine-d3 hydrochloride
  • HY-B0174AS2
    Olsalazine-d3,15N 98%
    Olsalazine-d3,15N is 15N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is an orally active prodrug of 5-ASA (HY-15027). Olsalazine can inhibit cells proliferation and induce apoptosis. Olsalazine can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.
    Olsalazine-d3,15N
  • HY-B0174AS3
    Olsalazine-d6 98%
    Olsalazine-d6 is the deuterium labeled Olsalazine (HY-B0174A). Olsalazine is an orally active prodrug of 5-ASA (HY-15027). Olsalazine can inhibit cells proliferation and induce apoptosis. Olsalazine can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.
    Olsalazine-d6
  • HY-B0178AS2
    Guanidine-13C hydrochloride 286013-04-5
    Guanidine-13C hydrochloride (Guanidinium-13C chloride) is the 13C-labeled Guanidine hydrochloride (HY-B0178A). Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins.
    Guanidine-13C hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity